King Hohenstaufen of Sicily and II. Frederick II from the Holy Roman Emperor founded the University of Naples on June 5, 1224, as an Imperial Statute, Studium. The founder was named Federico II in 1987. It is one of the oldest universities established by a president; This is different from other educational institutions that are the product of institutional initiatives. The aim of the king was to create a higher education institution that would end the sovereignty of the universities in northern Italy, especially Bologna and Padua, which were very independent or strongly influenced by the Pope. Independence was given by the Charter, which gave the Emperor the highest authority. He hired professors who would be royal employees paid with royal funds. Moreover, the emperor himself examined the candidates and the degrees were given. Consistent with this fairly rigid central organization, students and academic staff were not allowed to travel and work elsewhere. Alumni vowed to be loyal to the King and to teach at the stadium for at least sixteen months. The foundation of the university was carried out within the framework of an administrative reform followed by the Emperor in order to raise bureaucrats under his control and to keep the local nobles under control. Thus, a strong motivation was to create a political tool for the Emperor to maintain his policy and to oppose pope influence. However, Frederick’s love of learning was equally a powerful motivation. However, at the time of the Emperor’s reign, the university was closed, and in 1234 and 1239 it had to be re-established twice. After Frederick’s death, the university lost most of its glory and faced a period of instability, which was closed and re-established by the rulers. In conclusion, since 2000, a new, very large compound called the Monte Sant’Angelo Complex in the Fuorigrotta region has been hosted by the Faculties of Mathematics, Physics and Natural Sciences, Biotechnology Sciences and Economics. Although new universities have been established in southern Italy and Campania, student records in Naples have steadily increased over the course of the seventies and early 100s, making the University of Naples one of the largest in the country. Nowadays, the university consists of four schools, twenty-six departments, more than 3,000 people and more than 4,500 administrative staff. The current student registration is still about 100,000.